<s docid="FR940719-2-00089" num="13"> Discovery's deprenyl citrate is intended for the treatment of Alzheimer's disease.</s>

<s docid="FR940719-2-00089" num="21"> Background Discovery has submitted an NDA for deprenyl citrate with proposed labeling for the treatment of Alzheimer's disease.</s>

<s docid="FR940719-2-00089" num="36"> On November 29, 1991, Discovery submitted NDA 20-242 with data and information intended to demonstrate deprenyl citrate's safety and effectiveness in the treatment of Alzheimer's disease and proposed that the product be marketed without prescription.</s>

<s docid="FR940719-2-00089" num="69"> Discovery identified 12 of these 171 articles as evidence of the effectiveness of deprenyl citrate in the treatment of Alzheimer's disease.</s>

<s docid="FT942-8823" num="14"> Valium, the anti-depressant made by the Swiss company Hoffman-La Roche, was a patented drug whose success in the 1960s showed other groups how profitable the process could be.</s>

<s docid="FT942-8823" num="58"> It will continue to fight to extract full commercial value from Tagamet, but it sees its future in two new drugs with potential to match the sales Tagamet enjoyed in its heyday: anti-depressant Seroxat and anti-viral Famvir.</s>

<s docid="FT934-15392" num="39"> Upjohn has also signed an agreement with Geneva Pharmaceuticals, a subsidiary of Ciba of Switzerland, to market Xanax, an anti-anxiety treatment, and Halcion, the sleeping pill, whose patents expired last month.</s>

<s docid="LA090189-0106" num="9"> Federal officials are investigating Bolar Pharmaceutical Co. for possible fraud in connection with the approval of a generic version of the brand-name anti-depressant drug Mellaril.</s>

<s docid="LA090189-0106" num="13"> The generic drug now on the market, of the chemical thioridazine, is identical to Mellaril and is safe and effective, they said.</s>

<s docid="FT933-4868" num="8"> The success of the drug, clozapine, which was launched by Sandoz of Switzerland in the US in 1989, awakened a long-dormant interest in developing treatments for schizophrenia.</s>

<s docid="FT933-4868" num="10"> Among the most promising are risperidone and bromoperidol, both manufactured by Janssen, a Belgian subsidiary of Johnson & Johnson, and remoxipride, made by Astra in Sweden.</s>

<s docid="FT933-4868" num="24"> The first drug used in treating schizophrenia, thorozine, was discovered by accident.</s>

<s docid="FT933-4868" num="36"> 'For many of my patients, clozapine has seemed like a miracle,' says Robert McDivitt, trustee of the American Psychiatric Association.</s>

<s docid="FT933-4868" num="45"> Neuroleptics such as risperidone have generated a great deal of interest because they seem to deal with the sociability of the patient as well as the more serious problem of hallucinations.</s>

<s docid="FT922-715" num="32"> If so, a 5-HT3 antagonist such as ondansetron may help to restore the balance in several disorders, without side-effects.</s>

<s docid="FT922-715" num="35"> Eli Lilley of the US is already selling more than Dollars 1bn a year of its pioneering SSRI, fluoxetine (Prozac) launched in 1988.</s>

<s docid="FT922-715" num="36"> In hot pursuit is a second generation of SSRIs led by paroxetine (Seroxat), which was developed jointly by Novo Nordisk of Denmark and SmithKline Beecham, the Anglo-American group.</s>

<s docid="FT922-715" num="48"> They include piracetam from UCB of Belgium; oxiracetam from SmithKline Beecham; tacrine from Warner-Lambert of the US; and physostigmine from Forest Laboratories of the US.</s>

<s docid="FT922-715" num="52"> The drug (chemical name linopirdine) is noteworthy too for its unusually vivid and appealing trade name - Aviva.</s>

<s docid="LA070390-0063" num="24"> At that point, five hospital staff members held her down while she was injected with the drug Mellaril.</s>

<s docid="FT942-11804" num="57"> Companies in a similar position to Syntex include Upjohn, the US company which has seen patent run out on its biggest-selling products in recent months, for example on Xanax, an anti-depressive.</s>

<s docid="FT941-5246" num="23"> Even here the report says that money could be saved because a new generation of anti-depressives, which include Seroxat from SmithKline Beecham and Prozac from Eli Lilly, are up to 10 times as expensive as older drugs but no more effective.</s>

<s docid="LA062489-0059" num="33"> Riese had been taking the drug Thorazine but then refused further medication.</s>

<s docid="FT932-13133" num="33"> 'It was a brutal, primitive system,' says Stepanchuk, who was injected forcibly with various drugs including sulfazine, a powerful agent used widely on dissidents that causes fever, temporary paralysis and excruciating pain.</s>

<s docid="FT932-13133" num="69"> Insulin therapy is a brutal, painful treatment method which has gone the way of the lobotomy in western countries but continues to be seen in Russia as a miracle cure for schizophrenia.</s>

<s docid="LA090389-0060" num="22"> The problems of classical anti-schizophrenic medications such as Thorazine, Mellaril and Haldol include their awful side effects: uncontrollable -- and often irreversible -- tics and twitches, motor disturbances and persistent states of restlessness.</s>

<s docid="LA090389-0060" num="24"> One of those drugs, clozapine, is likely to be on the market for some schizophrenics by the end of the year, said Dr. Gilbert Honigfeld, who has led clozapine research for Sandoz Pharmaceuticals since 1973.</s>

<s docid="LA090389-0060" num="26"> Also, studies show that clozapine more effectively reaches schizophrenics who for unknown reasons do not respond well to the older drugs.</s>

<s docid="LA090389-0060" num="32"> As a result, if the Food and Drug Administration approves it for other than experimental use, clozapine will be restricted to the quarter-million or so schizophrenics who do not respond to the current drugs, Honigfeld said.</s>

<s docid="LA090389-0060" num="47"> It took seven years after the discovery of Thorazine in 1952 for a Swedish scientist to determine that the drug worked by interfering with the passage within the brain of a chemical called dopamine.</s>

<s docid="LA090389-0060" num="57"> Before Thorazine, patients were strapped in "tranquilizer chairs," spun around until they were dizzy, restrained much of the time and given high doses of insulin designed to plunge them into insulin shock, a procedure then thought to be therapeutic, Glazer said.</s>

<s docid="FT924-1386" num="61"> The leading SSRI is Prozac.</s>

<s docid="LA051490-0069" num="63"> These include fluoxetine (Prozac), a new antidepressant drug that helps reduce obsessive behavior.</s>

<s docid="FT924-3416" num="13"> These included Merrem, an antibiotic, Casodex, an anti-cancer agent, Accolate, an asthma drug, and a compound called 204636, designed to treat schizophrenia.</s>

<s docid="FT934-3850" num="38"> Zofran, also known as ondansetron, was as effective as Warner-Lambert's Cognex for the treatment of Alzheimer's symptoms and was far safer, said Dr Sykes.</s>

<s docid="FT934-11102" num="14"> Earlier this month, Xanax, an anti-anxiety drug and Halcion, a sleeping pill, lost their patent protection.</s>

<s docid="FT934-11102" num="37"> Other compounds in development include fluvoxamine, a treatment for obsessive compulsive disorder, which is being co-marketed with Solvay of Belgium.</s>

<s docid="LA112790-0137" num="100"> Lee said doctors there diagnosed her condition as postpartum depression and prescribed the anti-depressant drug Pamelor, the trade name for a generic drug known as nortriptyline.</s>

<s docid="LA092790-0201" num="37"> Haldol, a brand name for the drug haloperidol, is an anti-schizophrenic drug approved by the FDA and reimbursable by Medi-Cal.</s>

<s docid="FT923-11708" num="34"> Advocates for the mentally ill have attacked Swiss drug giant Sandoz for the price it has set for Clozapine, used to treat schizophrenia: Dollars 7,500 for the drug itself plus a required weekly blood monitoring.</s>

<s docid="LA010590-0095" num="13"> Clomipramine, sold under the trade name Anafranil, has been available on a special case-by-case basis to U.S. patients since June, 1988.</s>

<s docid="LA052790-0101" num="48"> A doctor had prescribed Haldol, an anti-psychotic, to treat a slight case of nervousness.</s>

<s docid="LA052690-0134" num="21"> Anti-psychotics like chlorprothixene and haloperidol have been reported to inhibit both ejaculation and orgasm, Segraves said.</s>

<s docid="LA052690-0134" num="26"> There have also been reports of the tranquilizer Valium and other members of the benzodiazepine drug family inhibiting ejaculation.</s>

